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. 2023 Jul 28;10:1227517. doi: 10.3389/fnut.2023.1227517

Table 1.

MS-based determinations of capsaicin in food and biological matrix.

Analytical method Matrix Analyte Reference
GC-MS Chili powder, chili sauce, and chili-flavored potato chips Capsaicin (30)
GC-qMS Five different types of Capsicum Capsaicin, dihydrocapsaicin, phenolic acids (31)
GC-qMS, GC-TOF-MS, GC-FID Capsicum at different ripening stages Capsaicins, amino acids, organic acids, sugars, sugar alcohols, free phenolic acids, carotenes, phytosterols, polyphenols, tocopherols, and volatile fatty acids (33)
LC-MS/MS Human and porcine hepatocyte components and a human lung cancer cell line (A549) Capsaicin, dihydrocapsaicin and their metabolites (34)
UPLC Q-Orbitrap HRMS/MS Human liver microsomes 19 phase I metabolites and 13 GSH complexes of capsaicin (35)
UHP-MS/MS Gutter oil Capsaicin, dihydrocapsaicin and n-vaninoamide (36)
DART-TOF-MS 46 varieties of Capsicum and their seeds Capsaicin (37)
MALDI-MS Perfume and herbs Capsaicin (38)
IR-MALDI-MS Mouse brain and Danaus plexippus caterpillar sections Capsaicin, dihydrocapsaicin and their metabolites (39)
TD-CFI-MS Chips, crisps, spicy peanuts, spicy vicia faba, spicy kelp silk, chili powder, sesame paste, peanut butter, sunflower seed oil, capsicol, mushroom sauce, medical tape, Guanjie zhitonggao patch, Shexiang zhentonggao patch, Lajiao fengshigao patch, and Shidishui tincture Capsaicin (40)