Table 1.

Radioprotective natural products and their regulated miRNAs.

Radioprotective Natural Product	Natural-Product-Regulated miRNAs	Radioprotective Natural Product	Natural-Product-Regulated miRNAs
Apigenin [169]	miR-15a-5p [170]	Withaferin A [16]	let-7c-5p, let-7a-5p [171]
Baicalein [10]	miR-3178 [172]		miR-549a-5p, miR-1247-5p, miR-124-5p, miR-137-5p [171], miR-10b-5p, miR-27a-3p [173] $\downarrow$
Celastrol [12]	miR-6085 [174] $\downarrow$	Chrysin [175]	miR-92a-3p [176], let-7a-5p, miR-9-5p, miR-22-3p [177], miR-34a-5p [177,178], miR-126-3p [177]
Chlorogenic acid [179]	miR-199a-5p [180]		miR-18a-5p [177], miR-21-5p [181,182], miR-221-3p [177] $\downarrow$
Daidzein [5]	miR-122-5p [183]
Diosmin [184]	miR-21-5p [181,182]	Delphinidin [185]	miR-23a-3p [186], miR-204-3p [187]
	miR-155-5p [181], miR-17-5p [188] $\downarrow$	Epigallocatechin gallate (EGCG) [189]	miR-30a-5p [190]
Melatonin [191]	miR-155-5p [192], miR-23a-3p [193] $\downarrow$
Silymarin [5]	miR-122-5p, miR-192-5p, miR-194-5p [194]	Ferulic acid [195]	miR-200c-3p [196]
			miR-340-3p [197] $\downarrow$
Thymol [198]	miR-29a-3p [199]	Ginsenoside Rg1 [17]	miR-126-3p [200]
Troxerutin [201]	miR-146a-5p [202], miR-147a [203]		miR-21-5p [181,182] $\downarrow$
Vitamin C [204]	miR-215-3p, miR-215-5p, miR-371b-5p, miR-181a-5p [205]	Ligustrazine [206]	miR-211-5p [207], miR-27a-3p [208]
			miR-16-5p [209] $\downarrow$
	miR-29b-1, miR-589-5p, miR-451a [210] $\downarrow$	Lycopene [211]	let-7f-1-3p [212]
			miR-27a-3p [213] $\downarrow$
Zingerone [214]	miR-200c-3p [215]	Piperine [216]	miR-181c-3p [217]
Berberine [9]	miR-182-5p [218]		miR-17-5p [219], miR-383-3p, miR-383-5p [220] $\downarrow$
Betulinic acid [221]	miR-27a-3p [222]	Resveratrol [223]	miR-34a-5p [224], miR-542-3p, miR-125b-5p [225] $\downarrow$
		Vitamin D [226]	miR-145-5p [227], miR-99b-3p [228], miR-15a-5p [170,228,229]
CAPE [230]	miR-3960 [231]
Carvacrol [198]	miR-217-3p, miR-217-5p [232]	Esculentoside A [233]
Curcumin [234]	miR-137-3p, miR-137-5p [235], miR-16-5p [236], miR-98-5p [237], miR-30a-5p [238]
		Allicin [239]
	miR-186-3p [240] $\downarrow$	Caffeine [241]
3,3′-Diindolylmethane [242]	miR-21-5p [181,182]	Chlorophyllin [243]
Emodin [15]	miR-1271-5p [244]	Dehydrozingerone [8]
Fucoidan [245]	miR-29b-3p [246], miR-29c-3p [247]	N-Acetyl tryptophan glucopyranoside [248]
	miR-17-5p [249] $\downarrow$
Gallic acid [250]	miR-182-5p [251], miR-518b [252]	Gymnemagenin [253]
	miR-21-5p [181,182] $\downarrow$
Genistein [254]	miR-574-3p [255]	Psoralidin [256]
	miR-27a-3p [257], miR-155-5p [258], miR-223-3p [259] $\downarrow$	Quinic acid [179]
Hesperidin [260]	miR-16-5p, miR-34a-5p [261], miR-132-3p [262]	Vanillin [263]
		Zymosan A [264]
	miR-21-5p [181,182] $\downarrow$	Dieckol [265]
Mangiferin [11]	miR-15b-5p [266], miR-27b-3p, miR-92a-3p [267]	Eckol [268]
Matrine [269]	miR-22-3p [177], miR-19b-3p [270]	Phloroglucinol [271]
	miR-21-5p [181,182] $\downarrow$
Parthenolide [272]	miR-107 [273]	Triphlorethol-A [274]
	miR-375-3p, miR-375-5p [275] $\downarrow$
Quercetin [276]	let-7a-5p [277], miR-146a-5p [277]	Diphlorethohydroxycarmalol [278]
	miR-21-5p [181,182] $\downarrow$
Rutin [279]	miR-590-5p [280], miR-877-3p [281], miR-129-1-3p [282]
		Laminaran [283]
Sesamol [284]	miR-370-3p [285]	β-carotene [286]
Ursolic acid [287]	miR-149-5p [288], miR-186-5p [289], miR-34c-5p [290]	Astaxanthin [291]
	miR-499a-5p [292] $\downarrow$	Cumaside [293]

$\downarrow$ indicates that miRNAs were downregulated by natural products, while miRNAs without $\downarrow$ indicate upregulation by natural products.