Table 5.

Exosome biogenesis-modulated target-centric chart of natural product *-regulated miRNAs.

Natural Product	miRNA	Exosome Biogenesis-Modulated Gene	Natural Product	miRNA	Exosome Biogenesis-Modulated Gene	Natural Product	miRNA	Exosome Biogenesis-Modulated Gene
Troxerutin	miR-147a	ATP9A	Delphinidin	miR-204-3p	RAB11A	Vitamin D	miR-145-5p	STAM
Berberine	miR-182-5p		3,3′-Diindolylmethane	miR-21-5p		Ursolic acid	miR-186-5p
Gallic acid	miR-182-5p		Diosmin	miR-21-5p		Ferulic acid	miR-200c-3p
Ursolic acid	miR-186-5p		Gallic acid	miR-21-5p $\downarrow$		Zingerone	miR-200c-3p
Chlorogenic acid	miR-199a-5p		Ginsenoside Rg1	miR-21-5p $\downarrow$		Genistein	miR-223-3p $\downarrow$
Carvacrol	miR-217-5p		Hesperidin	miR-21-5p $\downarrow$		Vitamin C	miR-371b-5p
Sesamol	miR-370-3p		Matrine	miR-21-5p $\downarrow$		Chrysin	miR-9-5p
Ursolic acid	miR-499a-5p $\downarrow$		Quercetin	miR-21-5p $\downarrow$		Chrysin	let-7a-5p	STEAP3
Chrysin	let-7a-5p	MYO5B	Chrysin	miR-21-5p $\downarrow$		Quercetin	let-7a-5p
Quercetin	let-7a-5p		Curcumin	miR-30a-5p		Withaferin A	let-7a-5p
Withaferin A	let-7a-5p		EGCG	miR-30a-5p		Withaferin A	let-7c-5p
Withaferin A	let-7c-5p		Ferulic acid	miR-340-3p $\downarrow$		Carvacrol	miR-217-5p
Emodin	miR-1271-5p		Sesamol	miR-370-3p		Chrysin	miR-9-5p
Apigenin	miR-15a-5p		Vitamin C	miR-371b-5p		Curcumin	miR-98-5p
Vitamin D	miR-15a-5p		Rutin	miR-590-5p		Diosmin	miR-17-5p $\downarrow$	TSG101
Mangiferin	miR-15b-5p		Emodin	miR-1271-5p	RAB27A	Fucoidan	miR-17-5p $\downarrow$
Curcumin	miR-16-5p		Ursolic acid	miR-186-5p		Piperine	miR-17-5p $\downarrow$
Hesperidin	miR-16-5p		Lycopene	let-7f-1-3p	RAB7A	Piperine	miR-383-3p
Ligustrazine	miR-16-5p		Emodin	miR-1271-5p		Parthenolide	miR-107	VPS4A
Diosmin	miR-17-5p $\downarrow$		Berberine	miR-182-5p		Ursolic acid	miR-149-5p
Fucoidan	miR-17-5p $\downarrow$		Gallic acid	miR-182-5p		Apigenin	miR-15a-5p
Piperine	miR-17-5p $\downarrow$		Chlorogenic acid	miR-199a-5p		Vitamin D	miR-15a-5p
Matrine	miR-19b-3p		Sesamol	miR-370-3p		Mangiferin	miR-15b-5p
Diosmin	miR-21-5p		Withaferin A	miR-10b-5p $\downarrow$	SDC1	Curcumin	miR-16-5p
Gallic acid	miR-21-5p $\downarrow$		Berberine	miR-182-5p		Hesperidin	miR-16-5p
Ginsenoside Rg1	miR-21-5p $\downarrow$		Gallic acid	miR-182-5p		Ligustrazine	miR-16-5p
Hesperidin	miR-21-5p $\downarrow$		Matrine	miR-19b-3p		Chrysin	miR-34a-5p
Matrine	miR-21-5p $\downarrow$		Chrysin	miR-9-5p		Hesperidin	miR-34a-5p
Quercetin	miR-21-5p $\downarrow$		Silymarin	miR-194-5p	SDC4	Resveratrol	miR-34a-5p $\downarrow$
Chrysin	miR-21-5p $\downarrow$		Withaferin A	miR-10b-5p $\downarrow$	SMPD3	Ursolic acid	miR-34c-5p
Genistein	miR-223-3p $\downarrow$		Betulinic acid	miR-27a-3p		Resveratrol	miR-125b-5p $\downarrow$	VPS4B
Rutin	miR-590-5p		Mangiferin	miR-27a-3p		Curcumin	miR-186-3p
Curcumin	miR-98-5p		Ligustrazine	miR-27a-3p		Ursolic acid	miR-186-5p
Carvacrol	miR-217-5p	PDCD6IP	Genistein	miR-27a-3p $\downarrow$		Matrine	miR-19b-3p
Chrysin	miR-221-3p $\downarrow$		Withaferin A	miR-27a-3p $\downarrow$		Carvacrol	miR-217-3p
Chrysin	miR-9-5p		Mangiferin	miR-27b-3p		Chrysin	miR-92a-3p
Vitamin C	miR-181a-5p		Silymarin	miR-29a-3p		Mangiferin	miR-92a-3p
Withaferin A	miR-124-5p $\downarrow$		Fucoidan	miR-29b-3p		Chrysin	miR-9-5p	CD34
Lycopene	let-7f-1-3p	SDCBP	Fucoidan	miR-29c-3p		Ursolic acid	miR-149-5p
Parthenolide	miR-107		Piperine	miR-383-3p		Vitamin C	miR-181a-5p	PRKN
Piperine	miR-383-3p		Chrysin	miR-9-5p		Ferulic acid	miR-200c-3p
Vitamin C	miR-371b-5p		Vitamin C	miR-29b-1 $\downarrow$	COPS5	Zingerone	miR-200c-3p
						Chlorogenic acid	miR-199a-5p	ATP13A2

* Natural products with modulating effects were derived from Table 1.$\downarrow$ indicates that miRNAs were downregulated by natural products, while miRNAs without $\downarrow$ were upregulated by natural products (retrieval date: 1 June 2023).