Table 2.

Major and minor diagnostic criteria for T-PLL defined by TPLL-ISG *.

Major Criteria
1. >5 × 109/L cells of T-PLL phenotype in peripheral blood or bone marrow
2. T-cell clonality (by polymerase chain reaction for T-cell receptor beta or gamma, or by flow cytometry)  3. Abnormalities of 14q32 or expression of TCL1A/B or MTCP1
Minor Criteria
1. Abnormalities of chromosome 11 (11q22.3, ATM)
2. Abnormalities of chromosome 8 [idic(8)(p11), t(8;8), or trisomy 8(q)] chromosome 5, 12, 13, or 22
3. Complex karyotype
4. Involvement of T-PLL specific site (e.g., splenomegaly or pleural effusions)

* Adapted from [3].