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Simplified presentation of the development and chronification of inflammatory processes by the impaired balance between pro- and anti-inflammatory cytokines, e.g., in rheumatoid arthritis. Abbreviations: GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; TGF, tumor necrosis growth factor; TH, T helper cell; TNF, tumor necrosis factor; Treg, regulatory T cell. The size of the cytokines depicted schematically represents their released amount.
