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This is a 69-year-old female with left breast invasive ductal carcinoma (ER+, PR+, and HER2+) who has received several rounds of HER2-targeted therapy, including ado-trastuzumab emtansine (TDM-1), and was on gemcitabine, trastuzumab, and pertuzumab therapy at the time of 89Zr-pertuzumab PET/CT. Tracer avidity was visualized in a known left supraclavicular lymph node metastasis (blue arrows), with SUVmax 5.1.
