Table 1.
Total lipid amount measured in organoids with the different genotypes.
| Class 1 | MM | MZ | ZZ | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Media (pmol) | SD * | Media (pmol) | SD | FC ** |
p-Value *** |
Media (pmol) | SD | FC |
p-Value *** |
||
| Cholesterol | Chol | 5070.61 | 488.56 | 5776.7 | 357.55 | 1.14 | 0.0352 | 5793.16 | 678.17 | 1.14 | 0.1075 |
| Phosphatidylcholine | PC | 3814.2 | 391.59 | 4848.09 | 426.64 | 1.27 | 0.0746 | 4116.96 | 398.06 | 1.08 | 0.3082 |
| Phosphatidylethanolamine | PE | 2116.96 | 207.09 | 2001.29 | 144.14 | 0.95 | 0.3366 | 2257.92 | 284.74 | 1.07 | 0.3556 |
| Phosphatidylserine | PS | 1076.2 | 145.32 | 1025.35 | 95.45 | 0.95 | 0.3933 | 1071.83 | 101.36 | 1 | 0.4908 |
| Triacylglycerol | TAG | 1065.28 | 60.73 | 3325.34 | 312.73 | 3.12 | 0.0079 | 3112.48 | 399.46 | 2.92 | 0.0168 |
| Phosphatidylinositol | PI | 525.25 | 26.77 | 775.52 | 41.67 | 1.48 | 0.0054 | 601.58 | 53.74 | 1.15 | 0.1475 |
| Phosphatidylethanolamine (-ether) | PE-O | 460.33 | 43.84 | 641.14 | 49.71 | 1.39 | 0.0267 | 868.37 | 108.36 | 1.89 | 0.0243 |
| Diacylglycerol | DAG | 376.61 | 25.09 | 417.04 | 39.62 | 1.11 | 0.2227 | 466.18 | 65.62 | 1.24 | 0.1527 |
| Sphingomyelin | SM | 290.89 | 31.92 | 350.47 | 22.77 | 1.2 | 0.1053 | 367.73 | 43.07 | 1.26 | 0.1154 |
| Ceramide | Cer | 231.32 | 18.2 | 363.72 | 18.65 | 1.57 | 0.0035 | 434.46 | 57.11 | 1.88 | 0.0297 |
| Hexosylceramide | HexCer | 87.76 | 9 | 41.95 | 1.72 | 0.48 | 0.0163 | 65.46 | 6.45 | 0.75 | 0.0608 |
| Phosphatidate | PA | 69.81 | 5.12 | 76.21 | 5.81 | 1.09 | 0.2279 | 83.79 | 10.23 | 1.2 | 0.1552 |
| Phosphatidylglycerol | PG | 47.58 | 4.89 | 60.24 | 4.36 | 1.27 | 0.0631 | 81.52 | 10.36 | 1.71 | 0.0317 |
| lyso-Phasphatidylethanolamine | LPE | 25.94 | 2.46 | 16.82 | 0.57 | 0.65 | 0.0295 | 44.62 | 5.14 | 1.72 | 0.0247 |
| Cardiolipins | CL | 25.06 | 1.6 | 54 | 2.69 | 2.15 | 0.001 | 47.67 | 7.27 | 1.9 | 0.0417 |
| Phosphatidylcholine (-ether) | PC-O | 24.71 | 2.34 | 50.62 | 4.23 | 2.05 | 0.0058 | 59.8 | 8.12 | 2.42 | 0.0204 |
| lyso-Phasphatidylcholine | LPC | 22.38 | 2.17 | 17.96 | 2.68 | 0.8 | 0.1359 | 49.03 | 4.96 | 2.19 | 0.0099 |
| Cholesterol esters | CE | 13.47 | 0.59 | 120.21 | 7.92 | 8.92 | 0.0026 | 173.25 | 24.02 | 12.86 | 0.0109 |
| lyso-Phasphatidate | LPA | 4.61 | 0.24 | 0 | 0 | 0 | 0.0014 | 7.48 | 1.04 | 1.62 | 0.0519 |
| lyso-Phosphatidylserine | LPS | 3.12 | 0.53 | 0.71 | 0.71 | 0.23 | 0.0287 | 4.28 | 0.49 | 1.37 | 0.092 |
| lyso-Phosphatidylinositol | LPI | 2.7 | 0.41 | 1.51 | 1.51 | 0.56 | 0.2583 | 2.54 | 0.32 | 0.94 | 0.3845 |
| lyso-Phosphatidylethanolamine (-ether) | LPE-O | 2.34 | 0.22 | 0 | 0 | 0 | 0.0043 | 6.6 | 0.72 | 2.81 | 0.01 |
| lyso-Phosphatidylglycerol | LPG | 1.59 | 0.1 | 0 | 0 | 0 | 0.0019 | 3.66 | 0.5 | 2.31 | 0.0246 |
| lyso-Phosphatidylcholine (-ether) | LPC-O | 0.86 | 0.18 | 0 | 0 | 0 | 0.0209 | 3.04 | 0.28 | 3.53 | 0.0025 |
1 Lipid species are ordered from most abundant to less abundant in MM-ORG, divided in the three groups of High abundant (>1000 pmol), Intermediate abundant (10 to 1000 pmol), and Low abundant (<10 pmol). * SD: Standard deviation; ** FC: Fold change; *** p-value is referred to in comparison with MM-ORG.