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. 2023 Jul 27;28(15):5686. doi: 10.3390/molecules28155686
ADME absorption, distribution, metabolism and excretion
AML acute myeloid leukemia
ATP adenosine triphosphate
AUC Area under curve
BBB blood brain barrier
BTZ Bortezomib
CAM chick chorioallantois membranes
CD2 catalytic domain 2
Cmax maximum serum concentration of drug in a specified compartment of the body
conc. concentrated
CRBN E3 ubiquitin cereblon ligase
DFMO difluoromethyl-1,3,4-oxadiazole
FA formic acid
GI50 concentration that causes 50% growth inhibition of cells
HB hydrogen bonding
HD Huntington disease
HDAC Histone deacetylase
HDACi Histone deacetylase inhibitor
HTS hight throughput screening
IC50 concentration that causes 50% enzyme inhibition
nM nanomolar
PBMCs peripheral blood mononuclear cells
PHA phytohemagglutinin
PROTAC proteolysis-targeting chimeras
SIRT Sirtuins
smHDAC HDAC from Schistosoma mansoni
t1/2 half-life period
TFMO trifluoro-1,2,4-oxadiazole
Tmax time of peak plasma concentration
VHL Von-Huppel–Lindau ligase
ZBG Zinc binding group
zHDAC6 zebrafish HDAC6