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. 2023 Jul 27;12(15):4945. doi: 10.3390/jcm12154945

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Biodistribution of CD8 PET imaging with 89Zr-Df-IAB22M2C in a 71-year-old male with metastatic melanoma on pembrolizumab for 28 days at the time of imaging. Maximal intensity projection images (A) show multinodal CD8+ involvement in the neck, axilla, and mediastinum. Please notice the low level of myocardial uptake on axial PET (B) and fused PET/CT (C) images make this radiotracer suitable for detecting checkpoint inhibitor myocarditis. Images courtesy of Dr. Michael Farwell from the University of Pennsylvania.