Table 2.
Incidence and most common vascular distribution of radiation-induced myocardial perfusion imaging abnormalities.
| Author; Year | N | Imaging Technique | Stress? | Months Post-RT |
Incidence of PD | p Value vs. Pre-RT | RT Dose (Gy) | Defect Location |
|---|---|---|---|---|---|---|---|---|
| Hardenbergh, 2001 [96] | 20 | SPECT | No | 6 | 60% | N/A | 46–50 | N/A |
| Lind, 2003 [97] | 69 | SPECT | No | 6 | N/A | <0.001 | 46–50 | LAD |
| Lind, 2003 [97] | 41 | SPECT | No | 12 | N/A | 0.07 | 46–50 | LAD |
| Lind, 2003 [97] | 16 | SPECT | No | 18 | N/A | 0.004 | 46–50 | LAD |
| Marks, 2005 [98] | 114 | SPECT | No | 6–24 | 32% | N/A | 46–50 | |
| Prosnitz, 2007 [102] | 44 | SPECT | No | 36–72 | 68% | N/A | 47.3 | LAD |
| Chung, 2012 [103] | 32 | SPECT/CT | Yes | 12 | 16% | 0.68 | 50–52.2 | N/A |
| Zellars, 2013 [104] | 43 | SPECT/CT | Yes | 6 | N/A | * 0.01 | 40–49 | LAD |
RT = radiation therapy; PD = perfusion deficit; LAD = left anterior descending coronary artery; SPECT = single photon emission computed tomography; CT = computed tomography. * p-value only significant for perfusion deficits at the apical segments during resting myocardial perfusion.