Figure 3.

Incidence of viral infections in endomyocardial biopsies of n = 872 virus-positive patients. A consecutive cohort of EMBs from 1132 patients with unclear heart failure was tested for presence of cardiotropic viruses via PCR. A total of 872 samples were virus positive (77%), of which B19V viral DNA alone (B19V DNA, 64.8%) or in combination with viral transcripts (B19V RNA, 21.3%) were the main contributors. SARS-CoV-2 constituted 1.9% of virus-positive cases. EV, HHV-6, EBV, and CMV, as well as co-infections therewith constitutes the remaining bulk of cases (14.1%). Detection of iciHHV-6 in heart failure patients was rare (0.2%).