Figure 8.

A unique design breeding funnel scheme showing the development of the collaborative cross (CC) mouse model. This breeding approach is designed to randomize the genetic makeup of each inbred line. A single breeding funnel results in one CC recombinant inbred line that represents the genomes of the eight CC mice founders. The eight founder strains are arranged in different positions (1–8) in each line, i.e., their order is randomized and not repeated across lines, and this order determines the funnel code based on a single letter code for each line. In a funnel breeding scheme, the genetic contributions of all eight founder strains are incorporated after the G2 generation. A recombinant inbred line is created following 20 generations of inbreeding [79].