Figure 1.

Sample state transition diagram for modeling treatment decisions in immune TTP [62]. Shown are the various health states possible for patients with TTP, which include the disease state (i.e., active TTP necessitating treatment), the remission state (no active TTP), exacerbation state and death. In this sample, relapse is a transitory event. All patients start in the disease state, with possibility of exacerbation, remission, and relapse back to disease. At all disease states, patients accrue background mortality risk, in addition to mortality specific to a given disease state.