Table 3.

Regulations/laws and regulatory requirements of dietary supplements in different countries (USA, EU, China, and Algeria) [13,22].

		USA	EU	China	Algeria
Regulatory agency		Food and Drug Administration (FDA)	–The European Commission and the competent authorities –EFSA (European Food Safety Authority), if centralized procedures apply	–CFDA (China Food and Drug Administration)	NA
Regulation and law		–FD & C Act (Federal Food, Drug, and Cosmetic Act) –DSHEA (Dietary Supplement Health and Education Act) –NLEA (Nutrition Labeling and Education Act) –CGMP (Current Good Manufacture Practice: manufacturing, packaging, labeling, or holding operations for DS)	–2002/46/EC –EC No 1924/2006	–Health Food Registration and Filing Regulation –Guidelines for the application of health food registration –Health Food Filing Work Guide –National food safety standard-Health foods GB 16740-2014 [23]	/
Compliance process		–The manufacturers and distributors are responsible –Notification/registration: DS containing a new ingredient	Notification/registration	–Registration: use the ingredients outside the raw material dictionary and excipient dictionary –Filing: use the ingredients listed in the raw material and excipient dictionary	/
Category	Foods	+	+	+	+
	Medicines	−	−	−	−
Manufacturer Registration		−	+ (Limited)	+	−
Presence of a positive list		−	+	+	NA
Good Manufacturing Practice (GMP)		+	+ (HACCP)	+	NA
Clinical trials of individual products		−	+ (New ingredients)	+ (New ingredients)	NA
Obligated to display the usage and dosage		+	+	+	NA
Serious adverse event reporting		+	+	−	NA
Labeling and packaging		+	+	+	NA
Shape description		+	+	Often	NA
Advertising requirements		+	+	+	NA
Health claims		−	−	−	NA

+/−: presence/absence of the factor; NA: not annotated.