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. 1990 Jul;74(7):417–420. doi: 10.1136/bjo.74.7.417

Outcome of iatrogenic choroidal neovascularisation in sickle cell disease.

P D Fox 1, R W Acheson 1, G R Serjeant 1
PMCID: PMC1042152  PMID: 1696123

Abstract

Choroidal neovascularisation developed in 62/66 (94%) eyes followed up for a mean period of 11.2 years after treatment with xenon arc feeder vessel coagulation for proliferative sickle retinopathy (PSR). In 27 eyes the neovascularisation was chorioretinal alone and in 35 eyes choriovitreal. Chorioretinal neovascularisation (CRN) was a benign complication but may convert to choriovitreal neovascularisation (CVN). Late sequelae of CVN included vitreous haemorrhage, posterior vitreous face fibrosis, and tractional retinal detachment. Visual loss (of greater than or equal to 3 Snellen lines for greater than or equal to 3 months) occurred in nine eyes affected by choroidal neovascularisation, though because of other pathology this could not always be attributed to the choroidal neovascularisation. The incidence of visual loss in CVN affected eyes was significantly greater, by survival curve analysis, than in eyes affected by CRN alone. Permanent visual loss from tractional retinal detachment definitely attributable to CVN occurred in 2/35 (6%) eyes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Archer D. B., Gardiner T. A. Morphologic fluorescein angiographic, and light microscopic features of experimental choroidal neovascularization. Am J Ophthalmol. 1981 Mar;91(3):297–311. doi: 10.1016/0002-9394(81)90281-6. [DOI] [PubMed] [Google Scholar]
  2. Carney M. D., Paylor R. R., Cunha-Vaz J. G., Jampol L. M., Goldberg M. F. Iatrogenic choroidal neovascularization in sickle cell retinopathy. Ophthalmology. 1986 Sep;93(9):1163–1168. doi: 10.1016/s0161-6420(86)33610-8. [DOI] [PubMed] [Google Scholar]
  3. Chandra S. R., Bresnick G. H., Davis M. D., Miller S. A., Myers F. Choroidovitreal neovascular ingrowth after photocoagulation for proliferative diabetic retinopathy. Arch Ophthalmol. 1980 Sep;98(9):1593–1599. doi: 10.1001/archopht.1980.01020040445010. [DOI] [PubMed] [Google Scholar]
  4. Condon P. I., Jampol L. M., Ford S. M., Serjeant G. R. Choroidal neovascularisation induced by photocoagulation in sickle cell disease. Br J Ophthalmol. 1981 Mar;65(3):192–197. doi: 10.1136/bjo.65.3.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Condon P. I., Serjeant G. R. Photocoagulation and diathermy in the treatment of proliferative sickle retinopathy. Br J Ophthalmol. 1974 Jul;58(7):650–662. doi: 10.1136/bjo.58.7.650. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Condon P. I., Serjeant G. R. Photocoagulation in proliferative sickle retinopathy: results of a 5-year study. Br J Ophthalmol. 1980 Nov;64(11):832–840. doi: 10.1136/bjo.64.11.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Condon P., Jampol L. M., Farber M. D., Rabb M., Serjeant G. A randomized clinical trial of feeder vessel photocoagulation of proliferative sickle cell retinopathy. II. Update and analysis of risk factors. Ophthalmology. 1984 Dec;91(12):1496–1498. doi: 10.1016/s0161-6420(84)34121-5. [DOI] [PubMed] [Google Scholar]
  8. Dizon-Moore R. V., Jampol L. M., Goldberg M. F. Chorioretinal and choriovitreal neovascularization. Their presence after photocoagulation of proliferative sickle cell retinopathy. Arch Ophthalmol. 1981 May;99(5):842–849. doi: 10.1001/archopht.1981.03930010842011. [DOI] [PubMed] [Google Scholar]
  9. Jampol L. M., Condon P., Farber M., Rabb M., Ford S., Serjeant G. A randomized clinical trial of feeder vessel photocoagulation of proliferative sickle cell retinopathy. I. Preliminary results. Ophthalmology. 1983 May;90(5):540–545. doi: 10.1016/s0161-6420(83)34537-1. [DOI] [PubMed] [Google Scholar]
  10. Moriarty B. J., Acheson R. W., Condon P. I., Serjeant G. R. Patterns of visual loss in untreated sickle cell retinopathy. Eye (Lond) 1988;2(Pt 3):330–335. doi: 10.1038/eye.1988.62. [DOI] [PubMed] [Google Scholar]
  11. Moriarty B. J., Acheson R. W., Serjeant G. R. Epiretinal membranes in sickle cell disease. Br J Ophthalmol. 1987 Jun;71(6):466–469. doi: 10.1136/bjo.71.6.466. [DOI] [PMC free article] [PubMed] [Google Scholar]

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