Table 3.
Association between allostatic load and mortality
| Allostatic load score |
No. deaths/person- years |
Deaths per 1,000 person-years (95% CI) |
Age-adjusted HR and 95% CI (N=1,291) |
aHR and 95% CIa (N=1,291) |
aHR and 95% CIb (N=1,291) |
|---|---|---|---|---|---|
| All-cause death | |||||
| 0 - 1 | 135/3,396.3 | 39.7 (33.4, 46.9) | REF | REF | REF |
| 2 - 3 | 292/5,158.3 | 56.6 (50.5, 63.3) | 1.47 (1.20, 1.80) | 1.33 (1.08, 1.65) | 1.26 (0.99, 1.61) |
| 4 - 9 | 119/1,784.8 | 66.7 (55.5, 79.3) | 1.88 (1.47, 2.41) | 1.52 (1.17, 1.98) | 1.27 (0.92, 1.74) |
| overall: 546/10339.4 | overall: 52.8 (48.6, 57.3) | p-trend < 0.01 | p-trend < 0.01 | p-trend = 0.08 | |
| Cancer-specific death | |||||
| 0 - 1 | 36/3,396.3 | 10.6 (7.4, 14.6) | REF | REF | REF |
| 2 - 3 | 83/5,158.3 | 16.1 (12.8, 19.9) | 1.53 (1.04, 2.27) | 1.40 (0.93, 2.11) | 1.17 (0.72, 1.88) |
| 4 - 9 | 39/1,784.8 | 21.9 (15.6, 29.8) | 2.17 (1.38, 3.42) | 1.80 (1.12, 2.90) | 1.50 (0.85, 2.65) |
| overall: 158/10339.4 | overall: 15.3 (13.0, 17.8) | p-trend < 0.01 | p-trend = 0.01 | p-trend = 0.17 | |
| Cardiovascular death | |||||
| 0 - 1 | 25/3,396.3 | 7.4 (4.8, 10.8) | REF | REF | REF |
| 2 - 3 | 60/5,158.3 | 11.6 (8.9, 14.9) | 1.65 (1.04, 2.64) | 1.52 (0.94, 2.47) | 1.74 (1.00, 3.01) |
| 4 - 9 | 21/1,784.8 | 11.8 (7.3, 17.9) | 1.89 (1.05, 3.37) | 1.59 (0.86, 2.94) | 1.32 (0.67, 2.60) |
| overall: 106/10339.4 | overall: 10.3 (8.4, 12.4) | p-trend = 0.02 | p-trend = 0.11 | p-trend = 0.20 |
Abbreviations: aHR: adjusted hazard ratio, CI: confidence interval, CVD: cardiovascular disease
a
The model adjusted for age, sex, race, education, marital status, smoking status, regular physical activity, energy intake, multimorbidity, time elapsed since cancer diagnosis, history of more than one cancer, and survey year.
b
The model corrected for the sampling weight and adjusted for the same set of covariates as the main model.