Table 4. Laboratory Markers Changes by Diet Group.
Values presented as LS MEANS (SE) rounded to the nearest whole number. Values are model based from the ITT analysis performed, including LS MEANS, change, and 95% CI.
| Parameter | Group | Baseline | Week 52 | Mean Change | 95% CI for Change | P-value |
|---|---|---|---|---|---|---|
| BP Systolic, mmHg | HP | 135 (2) | 126 (3) | −9 (2) | (−13.0, −5.1) | |
| NP | 135 (2) | 127 (3) | −8 (2) | (−12.2, −3.9) | 0.719 | |
| BP Diastolic, mmHg | HP | 86 (1) | 78 (1) | −7 (2) | (−10.2, −4.2) | |
| NP | 86 (1) | 81 (2) | −6 (2) | (−8.6, −2.3) | 0.430 | |
| Triglycerides, mg/dL | HP | 138 (9) | 114 (10) | −25 (9) | (−42.8, −6.1) | |
| NP | 139 (9) | 110 (10) | −29 (10) | (−48.0, −10.0) | 0.732 | |
| HDL Cholesterol, mg/dL | HP | 47 (1) | 47 (2) | 2 (1) | (−2.1, 2.9) | |
| NP | 45 (1) | 47 (2) | 1 (2) | (−0.8, 4.4) | 0.448 | |
| LDL Cholesterol, mg/dL | HP | 94 (4) | 91 (5) | −3 (4) | (−11.1, 4.6) | |
| NP | 95 (4) | 94 (5) | −1 (4) | (−9.3, 6.9) | 0.718 | |
| BUN | HP | 15 (1) | 17 (1) | 3 (1) | (1.5, 4.2) | |
| NP | 15 (6) | 18 (1) | 3 (1) | (1.2, 4.0) | 0.770 |
P-value represents differences in change between diet groups (HP vs. NP)
Mixed effects model used to test the effect of time, group, and their interaction term on changes in laboratory markers. Both diet groups reduced systolic and diastolic blood pressures and triglycerides from baseline to week 52. Neither group had changes in HDL or LDL cholesterol from baseline to week 52. Both groups increased BUN from baseline to week 52. There were no differences in change in any parameters by diet group (HP vs NP)
Abbreviations: BUN, blood urea nitrogen; BP, blood pressure; dL, deciliter; HDL, high‐density lipoprotein cholesterol; HP, high protein; LDL, low‐density lipoprotein cholesterol; mg, milligrams; mmHg, millimeters of mercury; NP, normal protein.