Table 1.
Kinetic parameters of BAT6026 and BAT6026-wt binding to Fcγ-RIIIa 158V or Fcγ-RIIIa 158F.
| Sample | FcγRIIIa 158F | FcγRIIIa 158V | ||||
|---|---|---|---|---|---|---|
| kon(1/Ms) | kdis(1/s) | kD a (M) | kon(1/Ms) | kdis(1/s) | kD a (M) | |
| BAT6026 | 3.37E+05 | 6.32E-02 | 1.88E-07 | 3.30E+05 | 1.87E-02 | 5.67E-08 |
| BAT6026-wt b | 4.52E+04 | 1.13E-01 | 2.51E-06 | 2.17E+05 | 1.05E-01 | 4.81E-07 |
FcgR, gamma Fc receptor; kon, association rate; kdis, dissociation rate; kD, equilibrium dissociation constant.
a
KD values are calculated from the ratio of the kinetic constants as KD = kdis/kon.
b
BAT6026-wt, the BAT6026 Fc variant with wilde type IgG1 Fc.