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. 2023 Jan 19;41(8):1089–1098. doi: 10.1038/s41587-022-01584-9

Table 2.

Susceptibility of M. pneumoniae and P. aeruginosa strains SAT290, PAO1 and C117 to different antibiotics

M. pneumoniae CV2_HA P. aeruginosa SAT290 PAO1 P. aeruginosa C117
Antibiotic Target Nonlethal Lethal Nonlethal Lethal Nonlethal Lethal Nonlethal Lethal
Piperacillin/tazobactam Cell wall 500 Nonlethal ND 5 50 100 200 500
Ciprofloxacin DNA gyrase ND 50 ND 50 ND 50 50 100
Levofloxacin DNA gyrase ND 20 ND 20 20 200 20 200
Meropenem Cell wall 500 Nonlethal ND 1 1 10 10 100
Imipenem/cilastatin Cell wall 500 Nonlethal ND 5 5 30 5 300
Amikacin Ribosome ND 10 10 100 ND 10 10 100
Ceftacidime/avibactam Cell wall 15 Nonlethal 0.5 15 5 15 15 ND
Ceftolozane/tazobactam Cell wall 15 Nonlethal ND 0.5 0.5 5 15 ND

Inoculum, growth and time are detailed in Methods. Numbers in the table represent the concentrations tested (µg ml−1) of each antibiotic. ND, Not determined.