Table 2.
M. pneumoniae CV2_HA | P. aeruginosa SAT290 | PAO1 | P. aeruginosa C117 | ||||||
---|---|---|---|---|---|---|---|---|---|
Antibiotic | Target | Nonlethal | Lethal | Nonlethal | Lethal | Nonlethal | Lethal | Nonlethal | Lethal |
Piperacillin/tazobactam | Cell wall | 500 | Nonlethal | ND | 5 | 50 | 100 | 200 | 500 |
Ciprofloxacin | DNA gyrase | ND | 50 | ND | 50 | ND | 50 | 50 | 100 |
Levofloxacin | DNA gyrase | ND | 20 | ND | 20 | 20 | 200 | 20 | 200 |
Meropenem | Cell wall | 500 | Nonlethal | ND | 1 | 1 | 10 | 10 | 100 |
Imipenem/cilastatin | Cell wall | 500 | Nonlethal | ND | 5 | 5 | 30 | 5 | 300 |
Amikacin | Ribosome | ND | 10 | 10 | 100 | ND | 10 | 10 | 100 |
Ceftacidime/avibactam | Cell wall | 15 | Nonlethal | 0.5 | 15 | 5 | 15 | 15 | ND |
Ceftolozane/tazobactam | Cell wall | 15 | Nonlethal | ND | 0.5 | 0.5 | 5 | 15 | ND |
Inoculum, growth and time are detailed in Methods. Numbers in the table represent the concentrations tested (µg ml−1) of each antibiotic. ND, Not determined.