Table IV.

Effect of oxcarbazepine suspension, oxcarbazepine gel and oxcarbazepine chitosan nanoparticles in gel on pilocarpine-induced seizures and lethality in adult rats

Treatment	Latency to first seizure (sec ± SEM)	Average seizure score (score /group ±SEM)	Status epilepticus (%)	24-hours survival (%)
PLC	2.64 ± 0.45	5.6 ± 0.33	80	20
OXC SUS	2.60 ± 0.60	5.9 ± 0.10	80	17
OXC GEL	3.80 ± 0.66	4.7 ± 0.47	30	50
OXC NP GEL	5.6 ± 0.73#$@	4.1 ± 0.45#$	27	50

PLC: group treated with pilocarpine; OXC SUS: group treated with oxcarbazepine suspension XC GEL; group treated with oxcarbazepine in gel; OXC NP; group treated with oxcarbazepine chitosan nanoparticles in gel. Statistical analysis was done using one-way ANOVA followed by Student-Newman-Keuls multiple comparison test. # p<0.05 vs PLC, $ p<0.05 vs OXC SUS, @ p<0.05 vs OXC GEL