Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 11;13:13075. doi: 10.1038/s41598-023-40402-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Optogenetic rescue normalizes neuronal calcium in APP mice. (A, B) The images pseudocolored according to the intraneuronal calcium concentration, acquired from APP mice expressing mCherry (A) or ChR2 (B). A neuronal process exhibiting calcium overload is seen in red (white arrows). (C) Histogram showing the distribution of YFP/CFP ratios in neurites expressing YC 3.6. Neuronal calcium overload was defined as a YFP/CFP ratio larger than 2 standard deviations above the average YFP/CFP ratio in the neurons of NTG mice. The ratio of YFP/CFP > 1.73 was considered as calcium overload. (D) The percentage of neurites exhibiting calcium overload after 2–4 week light activation of astrocytes. Values are mean ± SEM. Males are represented by closed circles and females by open circles. Scale bar, 100 μm, *p < 0.05.