Figure 4.

Disruption of TLR7-MyD88-TIRAP complex in loss-of-function (LOF) variants of TLR7. We have studied protein–protein interactions among TLR7, MyD88 and TIRAP using LZerD protein docking server in the presence and absence of TLR7 mutations. As shown in Fig. 1A, TLR7-MyD88-TIRAP complex formation helps in downstream signaling in the absence of TLR7 mutation. In LOF variants of TLR7, downstream signaling is impaired due to disruption of TLR7-MyD88-TIRAP complex as shown in Fig. 1B.