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. 2023 Aug 11;13:13078. doi: 10.1038/s41598-023-40114-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Association of TLR7 activity with MyD88 signaling and agonist binding. The heatmap analysis showed association of Loss-of-function TLR7 mutations with impaired MyD88 signaling and agonist binding. Certain hypofunctional variants are capable to form TLR7-MyD88-TIRAP complex and different TLR7 agonists can effectively bind to them. Neutral/benign variants form TLR7-MyD88-TIRAP complex and different TLR7 agonists can efficiently bind to them.