Table 2.

The clinicopathologic and molecular characteristics of 40 patients harboring NTRK fusions.

Case	Age (years)	Gender	Histologic diagnosis	Subtype	NTRK fusions	Fusion classification	Fusion type	TMB (muts/Mb)	MSI status	Fusion novelty
1	1	Female	Soft tissue sarcoma	Infantile fibrosarcoma	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	0	MSS	Reported
2	1	Male	Soft tissue sarcoma	Infantile fibrosarcoma	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	0	MSS	Reported
3	1	Female	Soft tissue sarcoma	Infantile fibrosarcoma	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	6.9	MSS	Reported
4	1	Female	Soft tissue sarcoma	Infantile fibrosarcoma	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	0.8	MSS	Reported
5	2	Female	Soft tissue sarcoma	Cellular plexiform schwannoma	TPM3-NTRK1	Definite fusion	Intrachromosomal rearrangement	0	MSS	Reported
6	2	Male	Soft tissue sarcoma	Infantile fibrosarcoma	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	3	MSS	Reported
7	3	Male	Soft tissue sarcoma	Rhabdomyosarcoma	LMNA-NTRK1	Definite fusion	Intrachromosomal rearrangement	1.2	MSS	Reported
8	4	Male	Soft tissue sarcoma	Infantile fibrosarcoma	TPM3-NTRK1	Definite fusion	Intrachromosomal rearrangement	0.7	MSS	Reported
9	9	Male	Soft tissue sarcoma	Soft tissue sarcoma of the abdomen	LMNA-NTRK1	Definite fusion	Intrachromosomal rearrangement	1.2	MSS	Reported
10	15	Male	Soft tissue sarcoma	Soft tissue sarcoma of the abdomen	LMNA-NTRK1	Definite fusion	Intrachromosomal rearrangement	0.6	MSS	Reported
11	23	Male	Carcinoma	Mucoepidermoid carcinoma of trachea	C7orf69-NTRK3	Likely fusion	Interchromosomal rearrangement	0	MSS	Novel
12	29	Male	Soft tissue sarcoma	Spindle cell sarcoma of the prostate	RBPMS-NTRK3	Definite fusion	Interchromosomal rearrangement	1.5	MSS	Reported
13	35	Male	Soft tissue sarcoma	Prostatic stromal tumor	IRF2BP2-NTRK1	Definite fusion	Intrachromosomal rearrangement	4.7	Unknown	Reported
14	38	Female	Carcinoma	Thyroid tumor	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	1.5	MSS	Reported
15	42	Female	Soft tissue sarcoma	Spindle cell sarcoma of the thigh	LMNA-NTRK1	Definite fusion	Intrachromosomal rearrangement	0.7	MSS	Reported
16	42	Male	Soft tissue sarcoma	Mucinous liposarcoma	MORF4L1-NTRK3	Definite fusion	Intrachromosomal rearrangement	0.7	MSS	Novel
16	42	Male	Soft tissue sarcoma	Mucinous liposarcoma	PPFIA2-NTRK3	Definite fusion	Interchromosomal rearrangement	0.7	MSS	Novel
17	43	Male	Soft tissue sarcoma	Spindle cell tumors of the sacrum	LMNA-NTRK1	Definite fusion	Intrachromosomal rearrangement	3	MSS	Reported
18	43	Female	Carcinoma	Non-small cell lung cancer	TPM3-NTRK1	Definite fusion	Intrachromosomal rearrangement	0.8	MSS	Reported
19	43	Male	Carcinoma	Small cell lung cancer	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	16.4	MSS	Reported
20	43	Male	Carcinoma	Gastric cancer	INSRR-NTRK1	Likely fusion	Intrachromosomal rearrangement	44.1	MSI-H	Novel
21	44	Male	Soft tissue sarcoma	High-grade spindle cell sarcoma of the small intestine	LMNA-NTRK1	Definite fusion	Intrachromosomal rearrangement	2.5	MSS	Reported
22	46	Male	Carcinoma	Intrahepatic cholangiocarcinoma	PHF20-NTRK1	Likely fusion	Interchromosomal rearrangement	42.5	MSI-H	Reported
23	48	Female	Carcinoma	Small cell lung cancer	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	14.8	MSS	Reported
24	48	Female	Carcinoma	Non-small cell lung cancer	RB1-NTRK3	Definite fusion	Interchromosomal rearrangement	5.4	MSS	Novel
25	48	Male	Carcinoma	Hepatocellular carcinoma	TTC28-NTRK3	Likely fusion	Interchromosomal rearrangement	6.9	MSS	Novel
26	52	Male	Carcinoma	Non-small cell lung cancer	AMOTL2-NTRK1	Likely fusion	Interchromosomal rearrangement	8.7	Unknown	Reported
27	53	Female	Carcinoma	Invasive breast cancer	LINC01197-NTRK3	Likely fusion	Intrachromosomal rearrangement	6.1	MSS	Novel
28	57	Male	Carcinoma	Colorectal cancer	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	180.3	MSI-H	Reported
29	59	Male	Carcinoma	Colorectal cancer	TPM3-NTRK1	Definite fusion	Intrachromosomal rearrangement	8.5	MSS	Reported
30	59	Female	Carcinoma	Ovarian serous cystadenocarcinoma	ITGA4-NTRK3	Definite fusion	Interchromosomal rearrangement	3.9	MSS	Novel
31	61	Female	Carcinoma	Colorectal cancer	TPM3-NTRK1	Definite fusion	Intrachromosomal rearrangement	8.5	MSS	Reported
32	61	Male	Carcinoma	Non-small cell lung cancer	COL8A1-NTRK3	Definite fusion	Interchromosomal rearrangement	10.8	MSS	Reported
33	63	Male	Carcinoma	Non-small cell lung cancer	PRDX1-NTRK1	Definite fusion	Intrachromosomal rearrangement	1.5	MSS	Novel
34	64	Male	Carcinoma	Hepatocellular carcinoma	PEAR1-NTRK1	Definite fusion	Intrachromosomal rearrangement	6.9	MSS	Reported
35	66	Male	Carcinoma	Extrahepatic cholangiocarcinoma	MMP16-NTRK3	Likely fusion	Interchromosomal rearrangement	6.1	MSS	Novel
36	67	Female	Soft tissue sarcoma	Uterine leiomyosarcoma	MEF2A-NTRK3	Definite fusion	Intrachromosomal rearrangement	3.8	MSS	Novel
37	69	Female	Carcinoma	Colorectal cancer	TPM3-NTRK1	Definite fusion	Intrachromosomal rearrangement	78.1	MSI-H	Reported
38	71	Female	Carcinoma	Colorectal cancer	TPR-NTRK1	Definite fusion	Intrachromosomal rearrangement	54.9	MSI-H	Reported
39	72	Male	Carcinoma	Colorectal cancer	ETV6-NTRK3	Definite fusion	Interchromosomal rearrangement	56.2	MSI-H	Reported
40	76	Male	Carcinoma	Colorectal cancer	LMNA-NTRK1	Definite fusion	Intrachromosomal rearrangement	6.2	MSS	Reported

Definite fusion: fusions with in-strand and in-frame state and the NTRK kinase domain.

Likely fusion: fusions with out-frame state in a known partner gene or in a hot exon and the NTRK kinase domain.