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. 2023 Aug 11;15:129. doi: 10.1186/s13148-023-01548-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — H3K9me3 profiles are globally correlated with negative growth change between birth and one year. a Average H3K9me3 profiles within peaks and 2 kb regions surrounding peaks. Each line represents an average profile of a child color coded by the child’s ΔHAZ (birth:1yr) score. The average profiles were normalized by drosophila spike-in normalization factors. b Spearman’s correlation coefficients (rho) between average normalized profile values from peak centers in (a) and a given measurement indicated on x axis. c PCA plot of H3K9me3 read counts in identified peaks. The numbers in brackets indicate variance explained by a given principal component. d Spearman’s correlation coefficients (rho) between PC1 and measurements indicated on x-axis. e Linear fit between ΔHAZ (birth:1yr) score and percentage of reads mapped to the Drosophila melanogaster genome. The relationship is significant (p-value = 0.021). Degrees of freedom = 13, adjusted R² = 0.296