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. 2023 Aug 11;15:129. doi: 10.1186/s13148-023-01548-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Misregulated H3K9me3 regions are enriched in transposable elements with potential roles in immune system modulation. a Ratio of observed over expected overlaps of TEs with top 10% significantly misregulated H3K9me3 regions with ΔHAZ (birth:1yr) score. Positive values indicate overlaps higher than expected. The color shows the total overlap size in base-pairs for a given TE class. b Top 20 GO:BP terms, as displayed by GREAT, associated with ERVs within the top 10% significantly affected H3K9me3 regions. Plotted are negative log₁₀ FDR-corrected p-values (padj). Padj values < 0.05 were considered significant. c Comparison of gene targets shared between enhancers with increased H3K27ac values at 18-weeks in stunting [36] and ERVs within the top 10% significant regions with increased H3K9me3 levels as illustrated in the top part of the panel. d Shared target genes between H3K27ac and ERVs from c. No significant functional enrichment was identified