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. 2023 Aug 12;22:133. doi: 10.1186/s12943-023-01825-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — STAT3 and PTEN are negatively correlated with mTORC1 in PCa. A Heatmaps depicting significant downregulation of STAT3 and PTEN mRNA levels and concomitant upregulation of EIF4EBP1 mRNA expression in prostate carcinoma patient samples (n = 13) compared with healthy prostate gland tissues (n = 8). Colors were normalized to depict relative mRNA expression values (log2 median-centered intensity) within each row; dark blue represents the lowest relative expression level and dark red represents the highest relative expression level. Data were extracted from the Oncomine™ Platform [59] and from the Arredouani Prostate study [55]. B Gene expression levels depicting significant downregulation of STAT3 (-1.57-fold) and PTEN (-1.26-fold) mRNA and concomitant upregulation of EIF4EBP1 mRNA (1.77-fold) in prostate carcinoma patients (n = 13) compared with normal prostate gland samples (n = 8). Data (log2 median-centered intensity) were extracted from the Oncomine™ Platform from the Arredouani Prostate dataset. Representation: boxes as interquartile range, horizontal line as the mean, whiskers as lower and upper limits. C Heatmap depicting significant downregulation of STAT3 and PTEN mRNA levels and concomitant upregulation of EIF4EBP1 mRNA expression in prostate carcinoma patients compared with normal prostate gland samples (log2 median-centered intensity). Data were extracted from the Oncomine™ Platform from the Lapointe Prostate dataset. D Gene expression levels depicting significant downregulation of STAT3 (-1.44-fold) and PTEN (-1.72-fold) mRNA and concomitant upregulation of EIF4EBP1 mRNA (1.37-fold) in prostate carcinoma patients (n = 59–62) compared with normal prostate gland samples (n = 37–41). Data (log2 median-centered intensity) were extracted from the Oncomine™ Platform from the Lapointe Prostate dataset. Representation: boxes as interquartile range, horizontal line as the mean, whiskers as lower and upper limits. E Boxplots representing protein expression of STAT3 and 4E-BP1 in cytoplasmatic or nuclear stainings detected by IHC in normal-like glands or tumors in PCa patient TMAs (n = 83)