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. Author manuscript; available in PMC: 2023 Aug 12.
Published in final edited form as: Sci Signal. 2023 May 9;16(784):eade4984. doi: 10.1126/scisignal.ade4984

Figure 2. Viral mRNA is visibly detectable in DRG and SC by ISH, but mature virus is not detectable by IHC.

Figure 2.

(A) Expression pattern of Spike RNA (red) around DAPI (blue) and Rbfox3 (white) in cervical and thoracic DRGs of SARS-CoV-2-infected and mock male hamsters at 1 dpi. Data are representative of n = 2 animals per group. (B) Expression patterns of Spike RNA (red) around DAPI (blue) in cervical and thoracic SC from SARS-CoV-2-infected and mock-control male hamsters at 1 dpi. Data are representative of n = 2 per group. (C) Nucleocapsid protein expression pattern in thoracic DRGs of SARS-CoV-2-infected and mock-control male hamsters, as well as lung tissue of male SARS-CoV-2-infected animals at 1 dpi. Data is representative of n = 2 animals per group. Scale bars: 50 μm; insets, 20 μm.