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Schematic diagram of all IHH-related PROKR2 mutations according the Gαq signaling pathway. The green dots represent neutral (N, AUC > 80% of WT PROKR2); the blue dots represent low pathogenicity (L, AUC 50–80% of WT PROKR2); the purple dots represent medium pathogenicity (M, AUC 20–50% of WT PROKR2) and the red dots represent high pathogenicity (H, AUC < 20% of WT PROKR2).
