Table 1.
Patients’ Characteristic
| Characteristics | Total N = 128 | Non-pCR N = 77 | pCR N = 51 | P value |
|---|---|---|---|---|
| Gender | 0.122 | |||
| Male | 114 (89.1) | 66 (85.7) | 48 (94.1) | |
| Female | 14 (10.9) | 11 (14.3) | 3 (5.9) | |
| Age (year), median (IQR) | 61.0 (56.3–66.0) | 61.0 (56.5–65.5) | 60.0 (56.0–66.0) | 0.682 |
| Smoking history | 0.067 | |||
| No | 31 (24.2) | 23 (29.9) | 8 (15.7) | |
| Yes, or ever | 97 (75.8) | 54 (70.1) | 43 (84.3) | |
| cT stagea | 0.512 | |||
| T1 | 9 (7.0) | 5 (6.5) | 4 (7.8) | |
| T2 | 57 (44.5) | 37 (48.1) | 20 (39.2) | |
| T3 | 37 (28.9) | 21 (27.3) | 16 (31.4) | |
| T4 | 25 (19.5) | 14 (18.2) | 11 (21.6) | |
| cN stagea | 0.396 | |||
| N0 | 15 (11.7) | 8 (10.4) | 7 (13.7) | |
| N1 | 26 (20.3) | 13 (16.9) | 13 (25.5) | |
| N2 | 69 (53.9) | 46 (59.7) | 23 (45.1) | |
| N3 | 18 (14.1) | 10 (13.0) | 8 (15.7) | |
| Differentiation degree | 0.012 | |||
| Moderate | 32 (25.0) | 25 (32.5) | 7 (13.7) | |
| Poor | 74 (57.8) | 42 (54.5) | 32 (62.7) | |
| Undifferentiated | 22 (17.2) | 10 (13.0) | 12 (23.5) | |
| Histological type | 0.042 | |||
| LUSC | 90 (70.3) | 48 (62.3) | 42 (82.4) | |
| LUAD | 21 (16.4) | 15 (19.5) | 6 (11.8) | |
| Othersb | 17 (13.3) | 14 (18.2) | 3 (5.9) | |
| PIV, median (IQR) | 371.97 (190.50–590.21) | 346.23 (185.77–547.84) | 488.54 (208.12–710.75) | 0.053 |
| NLR, median (IQR) | 2.51 (1.83–4.01) | 2.45 (1.83–3.84) | 2.85 (1.91–4.05) | 0.712 |
| MLR, median (IQR) | 0.26 (0.21–0.36) | 0.25 (0.19–0.34) | 0.28 (0.22–0.40) | 0.413 |
| PLR, median (IQR) | 157.50 (119.53–201.95) | 157.37 (117.17–201.41) | 159.50 (122.68–206.37) | 0.817 |
| PAR, median (IQR) | 6.70 (5.32–8.19) | 6.60 (5.24–7.85) | 6.92 (5.50–8.78) | 0.180 |
| SII, median (IQR) | 389.55 (234.22–760.14) | 382.88 (225.43–619.34) | 435.35 (242.78–793.21) | 0.914 |
| SIRI, median (IQR) | 1.35 (0.82–2.07) | 1.27 (0.81–1.74) | 1.44 (0.91–2.71) | 0.192 |
| PNI, median (IQR) | 52.33 (49.56–55.68) | 52.65 (49.78–55.86) | 51.13 (48.80–54.46) | 0.417 |
Notes: aDiagnosed based on the AJCC criteria (8th edition). bIncluding LELC, adenosquamous carcinoma, large cell neuroendocrine carcinoma. Bold values: P < 0.05.
Abbreviations: LUSC, lung squamous carcinoma; LUAD, lung adenocarcinoma; LELC, lung lymphoepithelioma-like carcinoma; PIV, pan-immune-inflammatory value; NLR, neutrophil–lymphocyte ratio; MLR, monocyte–lymphocyte ratio; PLR, platelet–lymphocyte ratio; PAR, platelet–albumin ratio; SII, systemic immune inflammation index; SIRI, system inflammation response index; PNI, prognostic nutritional index; IQR, interquartile ranges.