Table 2.
Full model summaries for Age 3 Verbal Index score in children of women with epilepsy (WWE) vs women without epilepsy (WWoE) and in children of women with epilepsy as a function of 3rd-trimester antiseizure medication (ASM) blood concentrations.
| Model Parameter | Parameter Estimate (95% CI) | P-value |
|---|---|---|
| Children of WWE and WWoE, Imputation Analysis (N = 371) | ||
| Mother’s Study Group: WWE vs WWoE | 0.4 (−2.4, 3.2) | 0.77 |
| Mother’s IQ | 0.3 (0.2, 0.4) | <.0001 |
| Child’s Sex: Male vs Female | −4.9 (−7.1, −2.6) | <.0001 |
| Child’s Ethnicity: Hispanic or Latino vs Non-Hispanic | −5.5 (−8.5, −2.6) | 0.0003 |
| Education Level | 0.0005 | |
| College Degree (Advanced) | Ref | - |
| College Degree (Not Advanced) | −1.7 (−4.6, 1.1) | 0.22 |
| No College Degree | −7.0 (−10.7, −3.3) | 0.0002 |
| Post-Birth Average Beck Anxiety Inventory score | −0.4 (−0.7, −0.2) | 0.0014 |
| Weeks Gestational Age at Enrollment | −0.3 (−0.5, 0.0) | 0.0462 |
| Mother’s Age at Enrollment | 0.2 (0.0, 0.5) | 0.06 |
| Children of WWE with 3 rd -Trimester Blood Concentrations, Imputation Analysis (N = 258) | ||
| 3rd-Trimester Max Observed Ratio ASM Blood Concentrationsa | −2.9 (−6.7, 1.0) | 0.15 |
| Mother’s IQ | 0.1 (0.0, 0.3) | 0.0235 |
| Child’s Sex: Male vs Female | −3.7 (−6.5, −1.0) | 0.0072 |
| Post-Birth Average Beck Anxiety Inventory score | −0.4 (−0.7, −0.1) | 0.0071 |
| Education Level | 0.0098 | |
| College Degree (Advanced) | Ref | - |
| College Degree (Not Advanced) | −2.5 (−6.0, 0.9) | 0.15 |
| No College Degree | −8.0 (−13.1, −2.9) | 0.0022 |
| Child’s Ethnicity: Hispanic or Latino vs Non-Hispanic | −4.8 (−8.6, −0.9) | 0.0156 |
| Weeks Gestational Age at Enrollment | −0.3 (−0.6, 0.0) | 0.0471 |
| Household Income | 0.11 | |
| $24,999 or less | Ref | - |
| $25,000–49,999 | 2.7 (−3.1, 8.5) | 0.37 |
| $50,000–74,999 | 5.0 (−0.8, 10.7) | 0.09 |
| $75,000–99,999 | 6.2 (0.1, 12.2) | 0.044 |
| $100,000 and up | 5.9 (0.3, 11.6) | 0.0379 |
| Subject desires not to answer | 9.9 (2.5, 17.3) | 0.0089 |
Variables selected into model using a stepwise selection algorithm with the completers population. Mother’s study group and IQ included in the first model a priori. Mother’s 3rd-trimester ratio ASM blood concentration and IQ included in the second model a priori. At each step, the model with the lowest Akaike information criterion was selected. Significance level for covariate entry was set to p = 0.10 and significance level to remain in the model was set to p = 0.15.
Ratio maximum observed ASM concentration, calculated as ratio upper limit for therapeutic range. For mothers on polytherapy, ratio ASM concentration calculated by summing the ratio ASM concentration for each ASM. Maximum observed value recorded during 3rd-trimester, including day of deliver