Table 2.
Clinico-pathological features associated with mismatch-repair deficiency
| Variable, n (%) | MMR deficient1 | MMR proficient2 | Adjusted OR (95% CI) | p Value |
|---|---|---|---|---|
| Age, y | ||||
| ≤31 | 8 (38.1) | 17 (21.0) | 5.16 (1.29 to 20.66) | 0.020 |
| >31 | 13 (61.9) | 64 (79.0) | ||
| Tumor Location | ||||
| Proximal to splenic flexure | 12(57.1) | 14(17.3) | 4.09 (1.26 to 13.27) | 0.019 |
| Distal to splenic flexure | 9(42.9) | 67(82.7) | ||
| MSI pathology 3 | ||||
| Yes | 19(90.5) | 35(43.2) | 13.38 (2.45 to 73.08) | 0.003 |
| No | 2(9.5) | 46(56.8) |
1
MSI and/or loss of expression of MMR proteins by immunohistochemistry.
2
MSS and normal expression of MMR proteins by immunohistochemistry.
3
Signet ring cells and/or Crohn’s-like lymphocytic reaction and/or tumor infiltrating lymphocytes and/or medullary growth pattern and/or anaplastic tumor.