Table 2.
Specimens and platforms used for baseline EGFR T790M molecular testing (full analysis set)
| Specimen source/testing platform | Full analysis set (N = 1350) |
|---|---|
| Specimen source and testing platform, n (%) | |
| Tissue | 783 (58.0) |
| Roche Cobas EGFR assay | 783 (100.0) |
| Blood | 567 (42.0) |
| Roche Cobas EGFR assay | 486 (85.7) |
| ddPCR | 56 (9.9) |
| AMOY | 16 (2.8) |
| EGFR mutation positive status, n (%) | |
| T790M | 1350 (100) |
| T790M + Exon 19 deletion | 793 (63.4) |
| T790M + L858R | 451 (36.1) |
| T790M + G719X | 6 (0.5) |
| Mutation combinations, n (%) | |
| T790M only | 89 (6.6) |
| T790M + common mutations | 1244 (92.1) |
| T790M + uncommon/compound mutations | 17 (1.3) |
| T790M + uncommon mutations | 6 (0.4) |
| T790M + common compound mutations | 5 (0.4) |
| T790M + uncommon compound mutations | 6 (0.4) |
Common mutations are T790M + Exon 19 Deletion only; T790M + L858R only. Uncommon mutations are T790M + G719X only; T790M + S768I only; T790M + Exon 20 Insertion only. Common compound mutations are T790M + 2 common mutations. Uncommon compound mutations are T790M + 2 or more mutations including at least 1 uncommon mutation
ddPCR droplet digital polymerase chain reaction, EGFR epidermal growth factor receptor