Fig. 10.

Dose adjustments of ARNI for specific patient populations. When making the transition from an ACEI to an ARNI, a 36-h washout period should be strictly observed to avoid angioedema, a delay that is not required when switching from an ARB to an ARNI. Please note that though the recommended starting dose for ARNI as per prescribing information by the innovator is 100 mg BD, Indian doctors recommend using 50 mg BD as the starting dose in Indian patients as per their clinical experience. eGFR estimated glomerular filtration rate, ARNI angiotensin receptor–neprilysin inhibitors, ACE angiotensin-converting enzyme, ARB angiotensin-receptor blocker-mineralocorticoid receptor antagonists, bd twice daily