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. 2023 Aug 12;14:4874. doi: 10.1038/s41467-023-40410-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Cryo-EM density of the asymmetric state of the TMEM16F dimer with the monomers colored blue and light blue, respectively, and the lipid densities in grey. The gaussian filtered cryo-EM density (semitransparent) reveals distortion of the lipid nanodisc. b Side view of a TMEM16F monomer (blue) highlighting the trail of lipids (grey) covering the TM region. c Front and side view of the atomic model of the asymmetric state of TMEM16F with Ca²⁺ atoms and glycans shown in green and red, respectively. The ion conduction channel identified by HOLE is represented by spheres colored in rainbow scale based on the local width of the channel, where red <1.5 Å and blue >7.5 Å.