Table 4.

Comparison of structural outcomes between the GLP-1RA and non-GLP-1RA groups

	GLP-1RA (n=188)	Non-GLP-1RA (n=1267)	Adjusted mean difference* (95% CI)	P value	Adjusted p value*
Interval of MRI scanning, years	4.5 (2.1)	4.3 (2.3)	-	0.28	-
Cartilage loss, mm	−0.17 (0.20)	−0.20 (0.20)	-	0.044	-
Cartilage loss velocity, mm/year	−0.05 (0.08)	−0.07 (0.10)	0.02 (0.002, 0.03)	0.004	0.026

*Mean difference and p value adjusted for age, sex, baseline BMI, baseline Kellgren-Lawrence grade and baseline WOMAC total score.

BMI, body mass index; GLP-1RA, glucagon-like peptide-1 receptor agonist; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.