Table 1.
Various characteristic features of human, mouse, pig, and bovine defensins
| Defensin name | Abbreviation | Chromosome | UniProt ID | Signal peptide | Mature defensin | Disulfide pattern in mature defensin |
|---|---|---|---|---|---|---|
| Human α-defensin | ||||||
| Neutrophil defensin-1 | HNP1 | 8 | P59665 | 1–19 | 66–94 | 66–94, 68–83, 73–93 |
| Neutrophil defensin 2 | HNP2 | 8 | P59666 | 1–19 | 64–94 | 66–94, 68–83, 73–93 |
| Neutrophil defensin 3 | HNP3 | 8 | P59666 | 1–19 | 65–94 | 66–94, 68–83, 73–93 |
| Neutrophil defensin 4 | HNP4 | 8 | P12838 | 1–19 | 66–96 | 65–93, 67–82, 72–92 |
| Human α-defensin-5 | HD5 | 8 | Q01523 | 1–19 | 63–94 | 65–93, 67–82, 72–92 |
| Human α-defensin 6 | HD6 | 8 | Q01524 | 1–19 | 69–100 | 72–99, 74–88, 78–98 |
| Human β-defensin | ||||||
| Human β-defensin-1 | hBD1 | 8 | P60022 | 1–21 | 33–68 | 37–66, 44–59, 49–57 |
| Human β-defensin 2 | hBD2 | 8 | O15263 | 1–23 | 24–64 | 31–60, 38–53, 43–61 |
| Human β-defensin 103A | hBD3 | 8 | P81534 | 1–22 | 23–67 | 33–62, 40–55, 45–63 |
| Human β-defensin 104A | hBD4 | 8 | Q8WTQ1 | 1–22 | 23–72 | 30–57, 37–51, 41–58 |
| Human β-defensin 105A | hBD5 | 8 | Q8IZN8 | 1–27 | 28–78 | 43–74, 53–67, 57–73 |
| Human β-defensin 6 | hBD6 | 8 | Q496I8 | 1–20 | 21–65 | 26–53, 33–47, 37–54 |
| Human β-defensin 109B | hBD9 | 8 | Q30KR1 | 1–22 | 23–87 | 31–59, 38–53, 43–60 |
| Human β-defensin 127 | hBD27 | 20 | Q9H1M4 | 1–20 | 21–63 | 24–53, 33–47, 37–54 |
| Human β-defensin 119 | DEFB20 | 20 | Q8N690 | 1–21 | 22–84 | 28–55, 35–49, 39–56 |
| Human β-defensin 126 | hBD26 | 20 | Q9BYW3 | 1–20 | 21–111 | 27–58, 34–52, 38–59 |
| Human β-defensin 118 | DEFB18 | 20 | Q8N690 | 1–19 | 20–62 | 27–54, 34–48, 38–55 |
| Human β-defensin 132 | hBD32 | 20 | Q7Z7B7 | 1–22 | 23–95 | 27–55, 35–49, 39–56 |
| Human β-defensin 107A | hBD7 | 8 | Q8IZN7 | 1–20 | 21–65 | 26–53, 33–47, 37–54 |
| Human β-defensin 114 | DEFB14 | 6 | Q30KQ6 | 1–26 | 27–69 | 29–57, 36–60, 40–58 |
| Human β-defensin 108B | hBD8 | 11 | Q496I8 | 1–26 | 27–56 | 27–55, 35–39, 37–56 |
| Mouse α-defensin | ||||||
| Mouse α-defensins-1 | Cryp1 | 8 | P11477 | 1–19 | 59–93 | 64–92, 66–81, 71–91 |
| Mouse α-defensins 2 | Cryp2 | 8 | Q8C1N9 | 1–19 | 20–95 | |
| Mouse α-defensins 3 | Cryp3 | 8 | P28310 | 1–16 | 59–93 | 64–92, 66–81, 71–91 |
| Mouse α-defensins 4 | Cryp4 | 8 | P28311 | 1–19 | 59–92 | 64–89, 66–81, 71–88 |
| Mouse α-defensins 5 | Cryp5 | 8 | L7N230 | 1–19 | 20–93 | |
| Mouse α-defensins 6 | Cryp6 | 8 | P28310 | 1–19 | 61–93 | 64–92, 66–81, 71–91 |
| Mouse α–defensins 17 | Cryp17 | 8 | P28310 | 1–16 | 59–93 | 64–92, 66–81, 71–91 |
| Mouse β-defensin | ||||||
| Mouse β-defensin-1 | mBD1 | 8 | P56386 | 1–21 | 33–69 | 37–66, 44–59, 49–67 |
| Mouse β-defensin 2 | mBD2 | 8 | P82020 | 1–20 | 21–71 | 37–66, 44–59, 49–67 |
| Mouse β-defensin 3 | mBD3 | 8 | Q9WTL0 | 1–20 | 23–63 | 31–59, 38–52, 42–60 |
| Mouse β-defensin 4 | mBD4 | 8 | P82019 | 1–22 | 23–63 | 31–59, 38–52, 42–60 |
| Mouse β-defensin 6 | mBD6 | 8 | Q91VD6 | 1–22 | 23–63 | 31–59, 38–52, 42–60 |
| Mouse β-defensin 7 | mBD7 | 8 | Q91V70 | 1–22 | 26–71 | 31–58, 38–52, 42–59 |
| Mouse β-defensin 9 | mBD9 | 8 | Q8R2I6 | 1–24 | 25–67 | 34–62, 41–55, 45–63 |
| Mouse β-defensin 10 | mBD10 | 8 | Q8R2I8 | 1–23 | 24–73 | 37–66, 44–59, 49–67 |
| Mouse β-defensin 11 | mBD11 | 8 | Q8R2I7 | 1–23 | 24–77 | 37–66, 44–59, 49–67 |
| Mouse β-defensin 12 | mBD12 | 8 | Q8K4N3 | 1–27 | 28–78 | 46–73, 53–67, 57–74 |
| Mouse β-defensin 14 | mBD14 | 8 | Q7TNV9 | 1–22 | 23–67 | 33–62, 40–55, 45–63 |
| Mouse β-defensin 19 | mBD19 | 8 | Q8K3I8 | 1–19 | 20–83 | 27–54, 34–48, 38–55 |
| Mouse β-defensin 20 | mBD20 | 2 | Q30KP3 | 1–21 | 22–96 | 24–52, 32–46, 36–53 |
| Mouse β-defensin 29 | mBD29 | 2 | Q8BGW9 | 1–23 | 24–78 | 40–67, 47–61, 51–68 |
| Mouse β-defensin 30 | mBD30 | 14 | Q30KN4 | 1–22 | 23–75 | 35–62, 42–56, 46–63 |
| Mouse β-defensin 41 | mBD17 | 8 | Q8K3I8 | 1–19 | 20–65 | 35–63, 42–56, 46–64 |
| Mouse β-defensin 42 | mBD42 | 14 | Q8BVB5 | 1–21 | 22–75 | 33–60, 40–54, 44–61 |
| Pig β-defensin | ||||||
| Pig β-defensin-1 | pBD1 | 15 | O62697 | 1–20 | 24–64 | 31–60, 38–53, 43–61 |
| Pig β-defensin 2 | pBD2 | 15 | Q6R953 | 1–21 | 22–69 | 37–65, 44–59,49–66 |
| Pig β-defensin 128 | pBD128 | 17 | A0A287BN95 | 1–19 | 20–94 | 25–52, 32–46, 36–53 |
| Pig β-defensin 121 | pBD123 | 17 | A0A8E8LS78 | 1–19 | 20–60 | 22–49, 29–43, 33–50 |
| Pig β-defensin 110 | pBD110 | 7 | A0A287BBL9 | 1–19 | 20–67 | 35–63, 42–56, 46–64 |
| Bovine β-defensin | ||||||
| Bovine β-defensin 4 | BNBD4 | 27 | P46162 | 1–22 | 23–63 | 31–60, 38–53, 43–61 |
| Bovine β-defensin-5 | BNBD5 | 27 | P46163 | 1–22 | 23–64 | 31–60, 38–53, 43–61 |
| Bovine β-defensin 7 | BNBD7 | 27 | P46165 | 1–22 | 23–62 | 31–60, 38–53, 43–61 |
| Bovine β-defensin 10 | BNBD10 | 27 | P46168 | 1–22 | 23–62 | 31–60, 38–53, 43–61 |
| Bovine β-defensin 119 | BNBD119 | 13 | Q32P86 | 1–20 | 21–83 | 27–54, 34–48, 38–55 |
| Bovine β-defensin 127 | BNBD127 | 13 | A0A3Q1N9G9 | 1–22 | 23–54 | 23–55, 33–49, 37–56 |