Abstract
Many patients with non-necrotising scleritis can be treated adequately with non-steroidal anti-inflammatory drugs or steroids. But, as many of them are young, treatment may present problems if they require high doses of steroids to control the scleral inflammation and then relapse when the dosage is reduced. Five such patients were treated with a combination of steroids and low-dose cyclosporin therapy, and in all cases the scleritis remained under control on a much lower dose of steroids than when steroids were used alone. Cyclosporin is therefore a useful drug in the management of younger patients dependent on high-dose steroids to control their scleral inflammation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Foster C. S. Immunosuppressive therapy for external ocular inflammatory disease. Ophthalmology. 1980 Feb;87(2):140–150. doi: 10.1016/s0161-6420(80)35272-x. [DOI] [PubMed] [Google Scholar]
- Nussenblatt R. B., Palestine A. G., Rook A. H., Scher I., Wacker W. B., Gery I. Treatment of intraocular inflammatory disease with cyclosporin A. Lancet. 1983 Jul 30;2(8344):235–238. doi: 10.1016/s0140-6736(83)90230-1. [DOI] [PubMed] [Google Scholar]
- Palestine A. G., Austin H. A., 3rd, Balow J. E., Antonovych T. T., Sabnis S. G., Preuss H. G., Nussenblatt R. B. Renal histopathologic alterations in patients treated with cyclosporine for uveitis. N Engl J Med. 1986 May 15;314(20):1293–1298. doi: 10.1056/NEJM198605153142005. [DOI] [PubMed] [Google Scholar]
- Sevel D. Necrogranulomatous keratitis associated with Wegener's granulomatosis and rheumatoid arthritis. Am J Ophthalmol. 1967 Feb;63(2):250–255. [PubMed] [Google Scholar]
- Tabbara K. F. Chlorambucil in Behçet's disease. A reappraisal. Ophthalmology. 1983 Aug;90(8):906–908. doi: 10.1016/s0161-6420(83)80014-1. [DOI] [PubMed] [Google Scholar]
- Towler H. M., Whiting P. H., Forrester J. V. Combination low dose cyclosporin A and steroid therapy in chronic intraocular inflammation. Eye (Lond) 1990;4(Pt 3):514–520. doi: 10.1038/eye.1990.68. [DOI] [PubMed] [Google Scholar]
- Wakefield D., McCluskey P. Cyclosporin therapy for severe scleritis. Br J Ophthalmol. 1989 Sep;73(9):743–746. doi: 10.1136/bjo.73.9.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Watson P. G. Doyne Memorial Lecture, 1982. The nature and the treatment of scleral inflammation. Trans Ophthalmol Soc U K. 1982 Jul;102(Pt 2):257–281. [PubMed] [Google Scholar]
- Young R. D., Watson P. G. Microscopical studies of necrotising scleritis. I. Cellular aspects. Br J Ophthalmol. 1984 Nov;68(11):770–780. doi: 10.1136/bjo.68.11.770. [DOI] [PMC free article] [PubMed] [Google Scholar]