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. 2023 Jun;80:102574. doi: 10.1016/j.sbi.2023.102574

Figure 1.

Figure 1

Structural snapshots of promiscuous GPCR-G protein coupling. Structural superposition of the GCGR coupled to Gs (blue) and Gi1 (red) showing similarities in TM6 (a) and differences in ICL2 (b) [10]. Structural superposition of the CCKAR coupled to Gq (green), Gi1 (red) and Gs (blue) showing similarities in TM6 position (c), differences in the ordering of ICL3 depending on the coupled G protein (d) and differences in the engagement mode of the α-subunit C-terminal ‘wavy hook’ for Gs vs Gq(e) [15,16].