Figure 2.

Milestones in the development of RNAi-based therapeutics

Timeline of important milestones since the discovery of the RNAi mechanism in 1998: 1998,¹ 2001,^5,22 2002,¹⁶ 2003,²³ 2004,^∗24,25 2005,²⁶ 2006,²⁷ 2008,^∗28,29 2011^,∗30 2014,^∗31 2017,^∗32 2018.^∗33,34,35 siRNA, short-interfering RNA; RISC, RNA-inducing silencing complex; shRNA, short hairpin RNA; wAMD, wet age-related macular degeneration; LNP, lipid nanoparticle; GalNAc, N-acetylgalactosamine. The asterisks before or after numbers indicate that the study mentioned is included in the published clinical trials analyzed in this systematic review. Created using BioRender.com.