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. 2023 Jul 18;33:469–482. doi: 10.1016/j.omtn.2023.07.018

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© 2023 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Delivery platforms of RNAi therapeutics

(A) Frequency distribution of methods used to deliver RNAi therapeutics to the target tissue used in the published and ongoing clinical trials from 2008 to 2023 and 2015 to 2023, respectively. See Table S4 for explanation of the “Ex vivo” category. (B) Frequency distribution of the types of NP types delivered in the published and ongoing clinical trials from 2008 to 2023 and 2015 to 2023, respectively. (C) Frequency distribution of the type of naked RNAi molecules used in the published and ongoing clinical trials from 2008 to 2023 and 2015 to 2023, respectively. Color-coded annotations are included for every distribution.