Figure 8.

Genome distribution of target loci

Heatmap showing the chromosomal location of genes targeted by RNAi therapeutics in the published (circles on the left chromosome) and ongoing clinical trials (circles on the right chromosome). Viral targets are shown below (circles on the left and right side of viruses depict the target in the published and ongoing clinical trials, respectively). Color-coded annotations are included on the right hand. Red refers to the highest number of studies targeting the mRNA of the given protein, whereas light blue refers to the lowest number of studies targeting the mRNA of the given protein (e.g., PCSK9 located on chromosome 1 encodes the PCSK9 protein. It is targeted 15 and 6 times in the published and ongoing clinical trials). Created using BioRender.com.