TABLE 1.
Molecular characterization of tumors induced by ΔMo+SRS MuLVs
| Virus | Animal | Genomic rearrangementsa
|
Insertion near cellular proto-oncogenesa
|
|||||
|---|---|---|---|---|---|---|---|---|
| TCR-β | IgH | Igκ | c-myc | Pim-1 | pvt-1 | evi-1 | ||
| ΔMo+SRS+M-MuLV | 498-1 | R | G | G | − | − | − | − |
| 498-2 | R | G | G | − | − | − | − | |
| 498-3 | R | G | G | + | − | − | − | |
| 498-4 | R | R | G | − | − | − | − | |
| 498-5 | R | R | G | − | − | − | − | |
| 498-6 | R | R | G | − | − | − | ND | |
| 498-7 | R | R | G | + | − | − | ND | |
| 527-12 | R | R | G | − | − | − | ND | |
| 527-13 | R | R | G | − | − | − | ND | |
| Total | 9/9 | 6/9 | 0/9 | 2/9 | 0/9 | 0/9 | 0/5 | |
| ΔMo+SRS−M-MuLV | 501-1 | R | R | G | − | − | − | − |
| 501-2 | R | R | G | − | − | − | − | |
| 501-3 | R | R | G | + | + | − | − | |
| Total | 3/3 | 3/3 | 0/3 | 1/3 | 1/3 | 0/3 | 0/3 | |
a
G, germ line; R, rearranged; ND, not done. Ratios indicate number of rearrangements per animal for each viral inoculum. Each animal had an enlarged thymus, spleen and lymph nodes.