Figure 3.

Altered gene expression associates with TRAF7 deficiency in mouse E9.5 embryos

(A) Venn diagram showing the overlap of DEGs in WT and Traf7^GLOko mouse embryos by RNA-seq analysis. Significant DEGs had both an absolute log2 fold change ≥1 and an FDR adjusted p value ≤0.05.

(B) Bubble plot of KEGG enrichment analysis of signaling pathways expressed in Traf7^GLOko versus WT embryos. Each bubble represents a KEGG pathway. Gene ratio (x axis) is the proportion of the total genes in a given pathway that is upregulated in the indicated group.

(C) Volcano plot of RNA-seq analysis visualizing significant DEGs in WT versus Traf7^GLOko embryos: magnitude of change (x axis) vs. statistically significant p values (y axis). Points with p value less than 0.05 or fold change less than 2 (log₂ = 1) are shown in blue.