Figure 5.

Conditional deletion of Traf7 in postnatal endothelium leads to brain hemorrhage

(A) Dorsal and ventral views of representative embryonic brains from P13 Traf7^iEChet and Traf7^iECko pups collected after daily tamoxifen administration.

(B) Quantification of brain hemorrhagic foci in Traf7^EChet (n = 8) and Traf7^ECko (n = 8) pups.

(C) H&E-stained coronal brain sections at the position indicated by the dotted blue line in (A).

(D) mRNA expression analysis of Klf2 and Klf4 in brains of P7 Traf7^iEChet versus Traf7^iECko pups. Each closed symbol represents an individual embryo. Bars show the Median. Asterisks indicate significant difference: (∗) p < 0.05; (ns) not significant.