Table 5. Detailed In Vitro Profiling of 30 (NPD-2975).
| assays | 30 |
|---|---|
| TbrPDEB1 inhibition | pKi < 5.0 |
| CYP450 IC50 | 1A2: 0.16 μM |
| 2C9: >10 μM | |
| 2C19: 0.42 μM | |
| 2D6: >10 μM | |
| 3A4: >10 μM | |
| hERG | >10 μM |
| mitochondrial toxicity | <10% toxicity at 10 μM |
| mini-ames | negative |
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