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(A) Radiolabeling of [18F]21. (B) Whole brain time activity curve (mean ± SD) of [18F]21 in rats (n = 4, 2F/2M). (C) PET summation images from rat PET scans using [18F]21 from 0 to 5 and 0–120 min. The first panel shows initial brain uptake, while the second panel shows likely skull uptake occurring over 120 min.
