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. 2023 Jul 24;66(15):10628–10638. doi: 10.1021/acs.jmedchem.3c00775

Table 8. Inhibition Constant (Ki) Values (n = 1) of 21 and Tau Radioligands in AD, PSP, and CBD Brain Homogenates.

    AD tissue PSP tissue CBD tissue
radioligand competitor Ki (nM) Ki (nM) Ki (nM)
[3H]PM-PBB3 21 22 18 19
[3H]CBD-2115 21 270 270 230
[3H]PI-2620 21 100 93 110