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. 2023 Feb;25(2):94–109. doi: 10.1016/j.jmoldx.2022.10.003

Figure 3.

Figure 3

Determination of thresholds for differentiating DNA mismatch repair (MMR)–deficient (dMMR) from MMR-proficient (pMMR) colorectal cancers (CRCs) using whole-exome sequencing (WES) data for each of the top 10 performing tumor features. Bar graphs presenting the distribution of tumors after applying the recommended thresholds (red line) for each of the top 10 predicting tumor features, MSMuTect, MANTIS, MSISensor, MSIseq, insertion/deletion (INDEL) count, tumor mutational burden (TMB), tumor mutational signature (TMS) small insertion/deletion (ID) 2 + ID7, TMS single-base substitution (SBS) 15, TMS SBS20, and TMS SBS54, as determined from the WES CRC analysis. Orange indicates pMMR, and blue represents dMMR status.