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. 2023 Jun 29;27(16):2448–2456. doi: 10.1111/jcmm.17834

FIGURE 5.

FIGURE 5

Schematic showing how pyroptosis may contribute to the pathogenesis of rheumatoid arthritis. In synovial cells, particularly macrophages, activation of the NLRP3/caspase‐1/gasdermin D pathway leads to pyroptosis. Caspase‐1 activates IL‐1β and IL‐18, which are released into the synovial fluid, while gasdermin D forms pores in the plasma membrane, leading to cytoplasmic swelling and ultimately to lysis, which releases lactate dehydrogenase and other cell contents into the synovial fluid.